This is an empirical cross-sectional study with the aim to examine the patient?s comprehension about their quality of life within two to seven years after their stem-cell transplantation with reference to physical, social, emotional, psychological and functional wellbeing and to investigate if the patient groups have disease specific problems. Differences in quality of life between men and women and also between allogeneic and Stem cell transplantation with an unrelated donor (URD) were studied. The measurement Functional Assessment of Cancer Therapy (FACT) and the bone marrow transplant subscale (BMT) is a 49 item, valid and reliable measure that was used. The questionnaire was answered by 43 of 47 patients (91%).There is a significant difference between men and women in physical, social and functional wellbeing.

This literature study aims to examine the existence of cancer stem cells in breast cancer. The cancer stem cell theory states that there is a hierarchical organization within a tumour, in which a small subpopulation of the cells can initiate new tumours and maintain tumour growth whilst the bulk of the tumour cannot. These tumour initiating cells have shown to possess many characteristics similar to those of adult stem cells, which is why they are often referred to as cancer stem cells. Both cell types have the capacity of asymmetric division and have shown to possess mechanisms of resistance to both apoptosis and cancer drugs. The cancer stem cell theory elucidates many biological aspects such as the heterogeneity of tumours and the relapse of many cancers after what appeared to be successful treatments.

The purpose of this paper is for the reader to realise how national innovation systems are deeply intertwined with the legal background of a country and to understand the processes that involves national innovation systems specifically regarding the stem cell / genetics research and how the need for specific community law must be considered targeting the stem cell patents. The legal part will try to answer: Why is it important given the actual state of the European stem cell national innovation systems for the European Commission to take a stand and tackle issues regarding the patenting of the human stem cell innovations? This is done from a country industry analysis (business approach) and then linking it with competition law from a community stand point of view (that tackles biotechnology issues). In order to achieve this the paper is divided into three separate analyses beginning with a theoretical background of general biotechnology / genetic terms that will enable the reader to have a general understanding of the importance of this kind or research ( genetics / stem cell research). The chosen countries case studies exemplify very diverse economies and development perspective from the traditionally R&D intensive to the least and from the biggest countries in Europe to one of the smallest, thus giving cultural, legal, economic and scientific variety..

When going through a Stem cell transplantation a patient is forced to undergo protective isolation to inhibit risk of opportunistic infections related to the low leucocyte count as a result of aggressive pre-transplant chemotherapy treatment. Protective isolation has shown to have an impact on patient experiences during treatment and the aim of this study is to elucidate experiences of protective isolation of patients undergoing hematopoietic Stem cell transplantation and to deduce patient perceptions of the role of nurses in protective isolation care. The presented study was performed as a mixed qualitative and quantitative survey at a hematopoietic ward in Sweden. Results were analyzed by Mayring (2000) and by descriptive frequency charts and show that patients in protective isolation experience alienation, necessity, safety and anxiety with regards to their protective situation. Considering the role of nurses patients perceive their role to be attendant, informant and acting as an executioner of medical implementations.

A possible treatment for patients with lymphoma and myeloma is Stem cell transplantation (SCT). SCT is preceded with cytostatic treatment. There are several side effects related to this treatment, for example fatigue, nausea, constipation/diarrhoea, pain, mucositis and loss of appetite. Aim: Investigate which side effects related to the treatment where most troubling after SCT and if nurse assessment and patient assessment differ. Methods: A quantitative empirical study with repeated measuring.

AbstractBackground: Pain is usually common patients who undergo high-dose treatment in combination with HSCT. Pain is usually associated with side effects as for example mucositis. The purpose of this study was to examine patients? experiences of pain in relation to stemcellstransplantation. The purpose was also to examine how patients experience that they have been treated by the personnel regarding their pain, and also if the pain relief correspond to the patients expectations.Method: The study is a descriptive, longitudinal study.

ABSTRACTMultiple sclerosis (MS) is the leading cause of adult disability inSweden. Hematopoietic Stem cell transplantation (HSCT) can be used as a treatment option for patients with MS where the disease has an aggressive course. The treatment is preceded by high-dose chemotherapy which lowers the patient's immune system. It is therefore of interest to study infectious complications associated with HSCT in this patient.Aim: The purpose of this study was to identify infection problems in this population associated with HSCT, and to study differences in infectious complications between this group and patients diagnosed with lymphoma who have undergone the same treatment.Method: The study was a retrospective descriptive study with quantitative data. A medical record review was conducted.

The cell cycle is the time a cell spends between two cell divisions. The cell cycle includes several parallel processes, all of which must be completed before a cell is mature for dividing. In the first place, all subcomponents (RNA, protein and membrane lipids) need to double in quantity and this occurs continuously through the cell cycle. Furthermore, the genome and some chromosomal proteins must double and this take place during a limited interval in the middle of the cell cycle (S-phase). On either side of the S-phase are two "gaps" which is called G1 and G2. When the cell has passed a point in the G-phase they are irreversibly programmed to progress through the remaining of the cell cycle and will undergo the next cell division. When a cell have passed a point in the G1 phase, approximately four hours after mitosis, a normal cell is in a state of indecision.

Väntan på transplantation kan vara en komplex situation för patient och anhörig. Studiens syfte var att belysa vad patienter och deras anhöriga upplever när de står i kö för en organtransplantation. Metoden som användes var en kvalitativ ansats där fyra självbiografier lästes och analyserades.I resultatet framkom att upplevelserna startade med beskedet om att transplantation var nödvändig för den fortsatta överlevnaden, tills beskedet om transplantation kom och patienterna lades in för operation.Analysen av den insamlade datan resulterade i fem kategorier: Insikten om sjukdomens allvar, Mellan hopp och förtvivlan, Tankar kring döden, Samvetskval och Ett efterlängtat besked. Resultatet kan användas till att öka förståelsen hos vårdpersonal för vad patienterna och deras anhöriga genomgår känslomässigt under deras väntan på organtransplantation..

Background: In Sweden, heart transplantation increases as a method of treatment. Patients undergoing heart transplantation require special needs of care. Nurses have to increase knowledge about experiences that these patients percieve to conform the health care in the future. In this study, health science has been used as a theoretical frame of reference which includes a patient perspective.Aim: The aim of this study was to describe experiences among patients, elder than 18 years old, undergoing heart transplantation.Method: The method was a qualitative descriptive study with a context analysis based on ten scientific articles and an autobiography corresponding with the aim of the study.Results: The results of this study showed six themes about experiences that emerged among patients undergoing heart transplantation: feeling of vitality, existential crisis, importance of social support, destructive feelings, capacity of going on and the experience of quality of life.Conclusion: It?s not a guarantee that the quality of life will increase among patients undergoing heart transplantation and they need a specialist trained nurse available to support at all hours..

Today?s cell phones include more and more functionality, it is no longer uncommon to be able to connect to the Internet or take photos with the cell phone. In this thesis the question is if the cell phone users are interested in this new functionality. Are there people who are interested in a cell phone that in this thesis is called ?Basmobilen? (the entry level phone), which include the following functions; phone call, SMS, phone book, calling lists, clock and the possibility to change the call signal.

The complexity of the mast cell is becoming more prominent. From being the cell recognized just to contribute to allergic inflammation it is now also associated with wound healing, protection against tumor growth and in recognition and defense against a wide range of pathogens. The location of the mast cell in the barrier between the external and internal environment of the body enables the cell to quickly respond to invading bacteria, virus and parasites. Diarrhea due to Escherichia coli infection, listeriosis, toxoplasmosis, Newcastle disease and bovine respiratory syncytial virus are examples of mast cell activating diseases that can affect animals in, as well as outside, the agricultural sector. Additionally, ticks and tick-borne diseases are of concern.

This report describes a Bachelor thesis work in which a robotised laser welding cell has been modelled and simulated for the purpose of making a presentation movie. The report shows that the work has been concentrated on making the movie from the modelling phase through the recording of the movie and ending up with the editing of the final presentation movie. A pre-study was made prior the Bachelor thesis work. In the pre-study a literature study was conducted about measurement and calibration of a welding cell. Measurement of almost all equipment in the entire cell was also conducted in the pre-study.

Introduktion Autolog stamcellstransplantation a?r idag en vanlig behandling vid myelom och ho?gmaligna lymfom hos patienter <65 a?r utan omfattande komorbiditet. Behandlingen delas upp i fem faser: induktionsbehandling, stamcellsmobilisering, stamcellssko?rd, konditionering med ho?gdoscytostatika och stamcellsa?tergivning/transplantation. Initialt behandlades alla patienter som genomgick autolog stamcellstransplantation inom slutenva?rden under den sista behandlingsfasen, det vill sa?ga i samband med konditionering och stamcellsa?tergivning.

Oxytocin is a hormone which plays a crucial role in many reproductive and behavioural functions. It affects many organs and the classical peripheral targets are the mammary glands during lactation and uterus during labour. Oxytocin receptors have recently been described in a variety of normal tissues and primary cell cultures, but also in neoplastic tissues and established neoplastic cell lines, as breast cancer cell lines. The signalling pathways and biological effects of the oxytocin/oxytocin receptor system seem to depend on species, type of tissue, physiological versus neoplastic state and receptor location within the cell membrane.The aim of this project was to find out if the cell proliferation in the canine mammary carcinoma cell line CMT-U27 was affected upon stimulation of oxytocin, and to investigate the presence of oxytocin receptors in these cells. The cell proliferation was examined by using an ELISA-kit, where the absorbance measured is relative to the amount of living cells.